its along the same lines as the power management disable of usb ports that i discussed in the basic forum.
viewtopic.php?f=7&t=12136lsusb, identify what ports you want to disable.
then traverse the /sys filesystem to find all the releated usb modules.
then , as an example, not necessarily an exact solution to your problem.
echo -n "0000:00:12.0" > /sys/bus/pci/drivers/ohci_hcd/unbind
you could add to that , again referring to the other thread a systemd script to run on bootup to add this line.
beware some usb ports may be used for keyboard/mouse.
regards peter