Wine vs Wine64 on x86_64

What is the most reasonable option to run regular 32bit Win applications on a 64bit linux system?
I had some issues with wine64+wine32 on Mandriva 2010 x86_64, when it took the applications 5-7 minutes to start, so I ended up with installing just a normal 32bit wine package.
Would it be safer to have just a 32bit wine on a 64-bit Mageia?
Thank you.
I had some issues with wine64+wine32 on Mandriva 2010 x86_64, when it took the applications 5-7 minutes to start, so I ended up with installing just a normal 32bit wine package.
Would it be safer to have just a 32bit wine on a 64-bit Mageia?
Thank you.