I usually trust the orphan removal and exercise it now and then - mostly to try that it is reliable, and for my usage it is.
What may be a problem is if you have installed something from third party that is dependant on a lib you remove, but not probable from what I see.
In short, you have a list of suggestions what to reinstall *if* needed
I would go ahead and let it work. (But it is still your decision of course
)If you want to be very careful:
Clearly you can at least safely uninstall lib64digikam* and lib64k3b*
If you do not use akonadi... corresponding packages there.
Lots of *kf5* and kmail, kpim, korganizer... but i think they are "just" for kmail etc, so if you do not use them...
Also, as your kernel works, I would uninstall the suggested kernel and virtualbox.
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Try again later to uninstall geoip-database. What is the error message? If drakrpm do not say clearly, try urpme.
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"flatpak update" updates installed flatpak applications, usually minor change in size, often bigger...
"flatpak uninstall --unused" cleans any no more used dependencies. One example is old no more used video drivers; newer may have been installed by the update command.