From way back I have experienced an annoying problem when installing ISOs in VirtualBox. This affects the installation process only.
Mouse pointer and keyboard capture is automatic but while navigating the installation screens I find that the VBox manager loses the mouse pointer after a few clicks. The pointer freezes and the host mouse pointer appears outside the box. It is possible to reactivate the guest pointer by moving the host pointer back over the Vbox screen. The guest pointer at this stage is restricted to a small portion of the window so some options cannot be reached unless the tab key is pressed. Using the capture key (Right Control) reestablishes full capture of the mouse pointer but this lasts for only a few clicks. This is a royal pain in the fundament and really slows the whole process down. Experiments with click-to-focus and focus-follows-mouse in the host did not solve the problem. My preference is for sloppy focus.
Once the installation is effected there is no more trouble. Mouse pointer capture works perfectly after reboot.
Has anybody else suffered this problem and managed to solve it?